IDSA 2023 Guidance on the Treatment of Antimicrobial Resistant Gram-Negative Infections

A Focus on Extended-spectrum β-lactamase-Producing Enterobacterales, AmpC β-Lactamase-Producing Enterobacterales, Carbapenem-Resistant Enterobacterales, Pseudomonas aeruginosa with Difficult-to-Treat Resistance, Carbapenem-Resistant Acinetobacter baumannii, and Stenotrophomonas maltophilia.

In the present document, guidance is provided on the treatment of infections caused by extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E), AmpC β-lactamase-producing Enterobacterales (AmpC-E), carbapenem-resistant Enterobacterales (CRE), Pseudomonas aeruginosa with difficult-to-treat resistance (DTR-P. aeruginosa), carbapenem-resistant Acinetobacter baumannii species (CRAB), and Stenotrophomonas maltophilia. Many of these pathogens have been designated urgent or serious threats by the CDC[2]. Each pathogen causes a wide range of infections that are encountered in United States hospitals of all sizes, and that carry with them significant morbidity and mortality.